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Article

Genetic Architecture of the Cardiovascular Risk Proteome.

Circulation - 13 Mar 2018

Benson Mark D, Yang Qiong, Ngo Debby, Zhu Yineng, Shen Dongxiao, Farrell Laurie A, Sinha Sumita, Keyes Michelle J, Vasan Ramachandran S, Larson Martin G, Smith J Gustav, Wang Thomas J, Gerszten Robert E

Abstract excerpt

BACKGROUND: We recently identified 156 proteins in human plasma that were each associated with the net Framingham Cardiovascular Disease Risk Score using an aptamer-based proteomic platform in Framingham Heart Study Offspring participants. Here we hypothesized that performing genome-wide association studies and exome array analyses on the levels of each of these 156 proteins might identify genetic determinants of...

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Identifiers

PMID: 29258991
DOI: 10.1161/CIRCULATIONAHA.117.029536
PMCID: PMC5849518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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