Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Fe/S cluster assembly protein Isd11 is essential for tRNA thiolation in Trypanosoma brucei.

The Journal of biological chemistry - 16 Jul 2010

Paris Zdenek, Changmai Piya, Rubio Mary Anne T, Zíková Alena, Stuart Kenneth D, Alfonzo Juan D, Lukes Julius

Abstract excerpt

Fe/S clusters are part of the active site of many enzymes and are essential for cell viability. In eukaryotes the cysteine desulfurase Nfs (IscS) donates the sulfur during Fe/S cluster assembly and was thought sufficient for this reaction. Moreover, Nfs is indispensable for tRNA thiolation, a modification generally required for tRNA function and protein synthesis. Recently, Isd11 was discovered as an integral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aconitate Hydratase
Share to Fumarate Hydratase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Iron-Sulfur Proteins

Share to Membrane Potential, Mitochondrial

Share to RNA, Protozoan

Share to RNA, Transfer

Share to Sulfhydryl Compounds

Share to Trypanosoma brucei brucei

Source

Open in PubMed Open full text

Identifiers

PMID: 20442400
DOI: 10.1074/jbc.M109.083774
PMCID: PMC2903368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Fe/S cluster assembly protein Isd11 is essential for tRNA thiolation in Trypanosoma brucei.PMID 20442400Read ↗

Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins.Semantic proximity Read ↗

The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins.Semantic proximity Read ↗

Iron-sulfur-protein biogenesis in eukaryotes.Semantic proximity Read ↗

Iron-sulfur cluster biosynthesis and trafficking - impact on human disease conditions.Semantic proximity Read ↗

Persulfide formation on mitochondrial cysteine desulfurase: enzyme activation by a eukaryote-specific interacting protein and Fe-S cluster synthesis.Semantic proximity Read ↗

Isd11p protein activates the mitochondrial cysteine desulfurase Nfs1p protein.Semantic proximity Read ↗

Mitochondrial iron-sulfur protein biogenesis and human disease.Semantic proximity Read ↗

The <i>Plasmodium falciparum</i> apicoplast cysteine desulfurase provides sulfur for both iron sulfur cluster assembly and tRNA modificationSemantic proximity Read ↗

A connection between two ancient and essential cellular processes, iron-sulfur protein biogenesis and fatty acid synthesis, in <i>Escherichia coli</i>Semantic proximity Read ↗

Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes.Semantic proximity Read ↗

Mammalian Fe-S cluster biogenesis and its implication in disease.Semantic proximity Read ↗

Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.