Back to search

Article

The <i>Plasmodium falciparum</i> apicoplast cysteine desulfurase provides sulfur for both iron sulfur cluster assembly and tRNA modification

2022-11-01

Abstract excerpt

Iron sulfur clusters (FeS) are ancient and ubiquitous protein cofactors that play fundamental roles in many aspects of cell biology. These cofactors cannot be scavenged or trafficked within a cell and thus must be synthesized in any subcellular compartment where they are required. We examined the FeS synthesis proteins found in the relict plastid organelle, called the apicoplast, of the human malaria parasite Pla...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6c07466a-6aed-566e-8436-778f03da51f0
DOI
10.1101/2022.10.31.514511
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The <i>Plasmodium falciparum</i> apicoplast cysteine desulfurase provides sulfur for both iron sulfur cluster assembly and tRNA modificationDOI 10.1101/2022.10.31.514511
Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in ToxoplasmaSemantic proximity
Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in ToxoplasmaSemantic proximity
A mutagenesis screen for essential plastid biogenesis genes in human malaria parasitesSemantic proximity
Genetic ablation of the mitochondrial ribosome in <i>Plasmodium falciparum</i> sensitizes the human malaria parasite to antimalarial drugs targeting mitochondrial functionsSemantic proximity
Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viabilitySemantic proximity
The Fe/S cluster assembly protein Isd11 is essential for tRNA thiolation in Trypanosoma brucei.Semantic proximity
A mutagenesis screen for essential plastid biogenesis genes in human malaria parasitesSemantic proximity
Iron-sulfur cluster biosynthesis and trafficking - impact on human disease conditions.Semantic proximity
Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functionsSemantic proximity
Localization of Fe‐S Biosynthesis Machinery in <i>Cryptosporidium parvum</i> MitosomeSemantic proximity
AtSufE is an essential activator of plastidic and mitochondrial desulfurases in Arabidopsis.Semantic proximity
The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins.Semantic proximity
Select a neighboring publication to make it the new centre.