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Article

Isd11p protein activates the mitochondrial cysteine desulfurase Nfs1p protein.

The Journal of biological chemistry - 4 Nov 2011

Pandey Alok, Yoon Heeyong, Lyver Elise R, Dancis Andrew, Pain Debkumar

Abstract excerpt

Cysteine desulfurases perform pyridoxal phosphate (PLP)-dependent desulfuration of cysteine. The key steps of the enzymatic cycle include substrate binding to PLP, formation of a covalent persulfide intermediate at the active site cysteine, and transfer of sulfur to recipients for use in various metabolic pathways. In Saccharomyces cerevisiae, the cysteine desulfurase Nfs1p and an accessory protein, Isd11p, are...

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Identifiers

PMID: 21908622
DOI: 10.1074/jbc.M111.288522
PMCID: PMC3207418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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