Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular determinants of microbial resistance to thiopeptide antibiotics.

Journal of the American Chemical Society - 26 May 2010

Baumann Sascha, Schoof Sebastian, Bolten Marcel, Haering Claudia, Takagi Motoki, Shin-ya Kazuo, Arndt Hans-Dieter

Abstract excerpt

Ribosomally produced thiopeptide antibiotics are highly promising lead compounds targeting the GTPase-associated region (GAR) of the bacterial ribosome. A representative panel of GAR mutants suspected to confer resistance against thiopeptide antibiotics was reconstituted in vitro and quantitatively studied with fluorescent probes. It was found that single-site mutations of the ribosomal 23S rRNA binding site...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacteria

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Survival

Share to Crystallography, X-Ray

Share to Drug Resistance, Bacterial

Share to Peptides

Share to RNA, Bacterial

Share to RNA, Ribosomal

Source

Identifiers

PMID: 20441189
DOI: 10.1021/ja909317n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular determinants of microbial resistance to thiopeptide antibiotics.PMID 20441189Read ↗

Mode of Action and Mechanisms of Resistance to the Unusual Polyglycosylated Thiopeptide Antibiotic Persiathiacin A.Semantic proximity Read ↗

Bio-inspired engineering of thiopeptide antibiotics advances the expansion of molecular diversity and utility.Semantic proximity Read ↗

The antibiotic thiostrepton inhibits a functional transition within protein L11 at the ribosomal GTPase centre.Semantic proximity Read ↗

Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor TuSemantic proximity Read ↗

Thiostrepton-resistant mutants of Thermus thermophilus.Semantic proximity Read ↗

Structural basis for cross-resistance to ribosomal PTC antibioticsSemantic proximity Read ↗

Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.Semantic proximity Read ↗

Macrolide resistance from the ribosome perspective.Semantic proximity Read ↗

The binding of thiostrepton to 23S ribosomal RNA.Semantic proximity Read ↗

Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4.Semantic proximity Read ↗

Macrolide antibiotic interaction and resistance on the bacterial ribosome.Semantic proximity Read ↗

Mutagenesis of the thiostrepton precursor peptide at Thr7 impacts both biosynthesis and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.