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Article

Thiostrepton-resistant mutants of Thermus thermophilus.

Nucleic acids research - 1 Jan 2004

Cameron Dale M, Thompson Jill, Gregory Steven T, March Paul E, Dahlberg Albert E

Abstract excerpt

Ribosomal protein L11 and its associated binding site on 23S rRNA together comprise one of the principle components that mediate interactions of translation factors with the ribosome. This site is also the target of the antibiotic thiostrepton, which has been proposed to act by preventing important structural transitions that occur in this region of the ribosome during protein synthesis. Here, we describe the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15199170
DOI: 10.1093/nar/gkh644
PMCID: PMC434449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Thiostrepton-resistant mutants of Thermus thermophilus.PMID 15199170Read ↗

Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain.Semantic proximity Read ↗

Phenotypic Suppression of Streptomycin Resistance by Mutations in Multiple Components of the Translation Apparatus.Semantic proximity Read ↗

Mutational analysis of 16S and 23S rRNA genes of Thermus thermophilus.Semantic proximity Read ↗

Streptomycin-resistant and streptomycin-dependent mutants of the extreme thermophile Thermus thermophilus.Semantic proximity Read ↗

The antibiotic thiostrepton inhibits a functional transition within protein L11 at the ribosomal GTPase centre.Semantic proximity Read ↗

Mutations in conserved helix 69 of 23S rRNA of Thermus thermophilus that affect capreomycin resistance but not posttranscriptional modifications.Semantic proximity Read ↗

Molecular determinants of microbial resistance to thiopeptide antibiotics.Semantic proximity Read ↗

Genetic and structural analysis of base substitutions in the central pseudoknot of Thermus thermophilus 16S ribosomal RNA.Semantic proximity Read ↗

Severity of the streptomycin resistance and streptomycin dependence phenotypes of ribosomal protein S12 of Thermus thermophilus depends on the identity of highly conserved amino acid residues.Semantic proximity Read ↗

The binding of thiostrepton to 23S ribosomal RNA.Semantic proximity Read ↗

Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4.Semantic proximity Read ↗

Alterations in ribosomal protein L19 that decrease the fidelity of translation.Semantic proximity Read ↗

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