Article
Macrolide resistance from the ribosome perspective.
Current drug targets. Infectious disorders - 1 Sept 2004
Franceschi F, Kanyo Z, Sherer E C, Sutcliffe J
Abstract excerpt
Macrolides are important antibiotics used in treatment of respiratory tract infections in humans. Although some of these compounds have been in use for 50 years, it has not been until the last few years that their mechanism of action and the nature of ribosomal-based resistance could be more fully understood. With the advent of robust crystals of ribosomal 50S subunits, and structural resolution of macrolides and...
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