The binding of thiostrepton to 23S ribosomal RNA.

doi:10.1016/0300-9084(91)90156-u

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Article

The binding of thiostrepton to 23S ribosomal RNA.

Biochimie - 1 Jan 2000

Thompson J, Cundliffe E

Abstract excerpt

The antibiotic, thiostrepton, binds to 23S ribosomal RNA from E coli with a dissociation constant (KD) of 2.4 x 10(-7) M. The specificity of the interaction was established using 16S rRNA and modified or mutationally-altered 23S rRNA. Thus, no binding was detected with rRNA from the 30S subunit n...

Topics

Binding Sites
Escherichia coli
Kinetics
Mutation
RNA, Bacterial
RNA, Ribosomal, 23S
Thiostrepton

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