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Article

Mutagenesis of the thiostrepton precursor peptide at Thr7 impacts both biosynthesis and function.

Chemical communications (Cambridge, England) - 14 Jan 2012

Li Chaoxuan, Zhang Feifei, Kelly Wendy L

Abstract excerpt

The seventh residue of thiostrepton is predicted to be critical for antibacterial activity. Substitution of Thr7 in the thiostrepton precursor peptide disrupts both biological activity and the successful biosynthesis of analogs.

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Identifiers

PMID: 22068975
DOI: 10.1039/c1cc14281j
PMCID: PMC3849712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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