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Article

Mode of Action and Mechanisms of Resistance to the Unusual Polyglycosylated Thiopeptide Antibiotic Persiathiacin A.

ACS infectious diseases - 10 Jan 2025

Woodgate Jason, Sumang Felaine A, Salliss Mary E, Belousoff Matthew, Ward Alan C, Challis Gregory L, Zenkin Nikolay, Errington Jeff, Dashti Yousef

Abstract excerpt

Persiathiacin A is a novel thiopeptide antibiotic produced by Actinokineospora species UTMC 2448. It has potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis. Thiopeptides, including persiathiacin A, exhibit antibacterial activity by inhibiting protein synthesis. In this study, we characterize the mechanism of action of persiathiacin A and investigate how...

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Identifiers

PMID: 39651842
DOI: 10.1021/acsinfecdis.4c00503
PMCID: PMC11731312

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