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Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu

1 Apr 2009

Abstract excerpt

We identified the thiomuracins, a novel family of thiopeptides produced by a rare-actinomycete bacterium typed as a Nonomuraea species, via a screen for inhibition of growth of the bacterial pathogen Staphylococcus aureus. Thiopeptides are a class of macrocyclic, highly modified peptides that are decorated by thiazoles and defined by a central six-membered heterocyclic ring system. Mining the genomes of...

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PMID: 19338336
DOI: 10.1021/ja900488a

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