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Article

The antibiotic thiostrepton inhibits a functional transition within protein L11 at the ribosomal GTPase centre.

Journal of molecular biology - 20 Feb 1998

Porse B T, Leviev I, Mankin A S, Garrett R A

Abstract excerpt

A newly identified class of highly thiostrepton-resistant mutants of the archaeon Halobacterium halobium carry a missense mutation at codon 18 within the gene encoding ribosomal protein L11. In the mutant proteins, a proline, conserved in archaea and bacteria, is converted to either serine or threonine. The mutations do not impair either the assembly of the mutant L11 into 70 S ribosomes in vivo or the binding of...

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Identifiers

PMID: 9512711
DOI: 10.1006/jmbi.1997.1541

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