Article
The antibiotic thiostrepton inhibits a functional transition within protein L11 at the ribosomal GTPase centre.
Journal of molecular biology - 20 Feb 1998
Porse B T, Leviev I, Mankin A S, Garrett R A
Abstract excerpt
A newly identified class of highly thiostrepton-resistant mutants of the archaeon Halobacterium halobium carry a missense mutation at codon 18 within the gene encoding ribosomal protein L11. In the mutant proteins, a proline, conserved in archaea and bacteria, is converted to either serine or thr...
Topics
- Amino Acid Sequence
- Anti-Bacterial Agents
- DNA Footprinting
- Drug Resistance, Microbial
- GTP Phosphohydrolases
- Halobacterium salinarum
- Molecular Sequence Data
- Mutation
- RNA
- RNA, Ribosomal, 23S
- Recombinant Fusion Proteins