Article
DNA damage response and tumorigenesis in Mcm2-deficient mice.
Oncogene - 24 Jun 2010
Kunnev D, Rusiniak M E, Kudla A, Freeland A, Cady G K, Pruitt S C
Abstract excerpt
Minichromosome maintenance proteins (Mcm's) are components of the DNA replication licensing complex. In vivo, reduced expression or activity of Mcm's has been shown to result in highly penetrant early onset cancers (Shima et al., 2007; Pruitt et al., 2007) and stem cell deficiencies (Pruitt et al., 2007). Here we use mouse embryonic fibroblasts from an Mcm2-deficient strain of mice to show by DNA fiber analysis...
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