Article
Genetic instability as a consequence of inappropriate entry into and progression through S-phase.
Cancer metastasis reviews - 1 Mar 1995
Almasan A, Linke S P, Paulson T G, Huang L C, Wahl G M
Abstract excerpt
The stability of the mammalian genome depends on the proper function of G1 and G2 cell cycle control mechanisms. Two tumor suppressors, p53 and retinoblastoma (Rb), play key roles in progression from G1 into S-phase. We address the mechanisms by which these proteins mediate a G1 arrest in respons...
Topics
- Animals
- Antimetabolites
- Apoptosis
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Damage
- G1 Phase
- Gene Expression Regulation
- Genes, Retinoblastoma
- Genes, p53
- Genome
- Humans
- Mutation
- Neoplasms
- Peptide Elongation Factor 2
- Peptide Elongation Factors