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Article

Genetic instability as a consequence of inappropriate entry into and progression through S-phase.

Cancer metastasis reviews - 1 Mar 1995

Almasan A, Linke S P, Paulson T G, Huang L C, Wahl G M

Abstract excerpt

The stability of the mammalian genome depends on the proper function of G1 and G2 cell cycle control mechanisms. Two tumor suppressors, p53 and retinoblastoma (Rb), play key roles in progression from G1 into S-phase. We address the mechanisms by which these proteins mediate a G1 arrest in response to DNA damage and limiting metabolic conditions. Gamma-irradiation induced a prolonged, p53-dependent G1 arrest...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7606822
DOI: 10.1007/BF00690212

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic instability as a consequence of inappropriate entry into and progression through S-phase.PMID 7606822Read ↗

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