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Article

IL-15 has innate anti-tumor activity independent of NK and CD8 T cells.

Journal of leukocyte biology - 1 Sept 2010

Davies Elizabeth, Reid Sarah, Medina Maria Fe, Lichty Brian, Ashkar Ali A

Abstract excerpt

The innate immune system is crucial for host defense and immunosurveillance against pathogens and tumor cells. IL-15 is a pleiotropic cytokine with important effects on cells of the innate and adaptive immune systems. The NK cell- and CD8(+) T cell-mediated functions of IL-15 against tumor cells have been well documented. However, it has not been established whether IL-15 has innate anti-tumor functions...

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PMID: 20538758
DOI: 10.1189/jlb.0909648

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