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Humanized mouse model supports development, function, and tissue residency of human natural killer cells

25 Oct 2017

Abstract excerpt

Significance Humanized mice represent a promising approach to study the human immune system in health and disease. However, insufficient development and function of human lymphocytes limit the applicability of humanized mice for cancer biology and therapy. We demonstrate that human SIRPA and IL15 knock-in (SRG-15) mice support efficient development of circulating and tissue-resident natural killer (NK) cells,...

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PMID: 29078283
DOI: 10.1073/pnas.1705301114

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