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Article

An antagonist mutant IL-15/Fc promotes transplant tolerance.

Transplantation - 15 Jan 2006

Zheng Xin Xiao, Gao Wei, Donskoy Elina, Neuberg Manfred, Ruediger Manfred, Strom Terry B, Moll Thomas

Abstract excerpt

BACKGROUND: IL-15 is a proinflammatory and antiapoptotic T-cell growth factor that plays an important role in a variety of autoimmune disorders and transplant rejection. To inhibit IL-15 function and to target IL-15 receptor (IL-15R) bearing cells, we have generated a unique lytic antagonistic mutant IL-15/Fc fusion protein (mIL-15/Fc). METHODS: In this study, we further examined the efficacy of mIL-15/Fc in...

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Source

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Identifiers

PMID: 16421485
DOI: 10.1097/01.tp.0000188139.11931.98
PMCID: PMC4329733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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