Article

Interleukin-15 Receptor α Chain Knockout NOD-SCID mice have reduced numbers of NK cells, develop thymic lymphomas and fail to engraft human hematopoietic cells

2021-04-22

Abstract excerpt

NOD-SCID IL2rγ c null (NSG) mice are widely used to model human immune cell development because they are more permissive for human hematopoietic cell engraftment and reconstitution than NOD-SCID mice. While increased human reconstitution in the blood of NSG mice has been attributed to the absence of mouse NK cells, deletion of the common gamma chain (γc) limits development of lymphoid tissue inducer cells and pre...

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Literature Corpus work: e9362adb-68d7-5d41-9eda-2d5f8a9811e2
DOI: 10.1101/2021.04.22.440980

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