Article
Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells.
The Journal of experimental medicine - 15 Jan 2001
Fehniger T A, Suzuki K, Ponnappan A, VanDeusen J B, Cooper M A, Florea S M, Freud A G, Robinson M L, Durbin J, Caligiuri M A
Abstract excerpt
Inflammation likely has a role in the early genesis of certain malignancies. Interleukin (IL)-15, a proinflammatory cytokine and growth factor, is required for lymphocyte homeostasis. Intriguingly, the expression of IL-15 protein is tightly controlled by multiple posttranscriptional mechanisms. Here, we engineered a transgenic mouse to overexpress IL-15 by eliminating these posttranscriptional checkpoints. IL-15...
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