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Article

Association between normal tissue complications after radiotherapy and polymorphic variations in TGFB1 and XRCC1 genes.

Radiation research - 1 Apr 2010

Alsbeih G, Al-Harbi N, Al-Hadyan K, El-Sebaie M, Al-Rajhi N

Abstract excerpt

Genetic predictive biomarkers of radiosensitivity are being sought to individualize radiation treatment of cancer patients. In this pilot case-control study, we tested the association between TGFB1 T869C codon 10 Leu/Pro (rs1982073), XRCC1 G28152A codon 399 Arg/Gln (rs25487), and XRCC3 C18067T codon 241 Thr/Met (rs861539) single-nucleotide polymorphisms (SNPs) and late reaction to radiotherapy in 60...

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Source

Identifiers

PMID: 20334523
DOI: 10.1667/RR1769.1

Genes

TGFB1
XRCC1
XRCC3

Variants

rs1982073
rs1982073
rs1982073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Association between normal tissue complications after radiotherapy and polymorphic variations in TGFB1 and XRCC1 genes.PMID 20334523Read ↗

Can risk of radiotherapy-induced normal tissue complications be predicted from genetic profiles?Semantic proximity Read ↗

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Common variants of GSTP1, GSTA1, and TGFβ1 are associated with the risk of radiation-induced fibrosis in breast cancer patients.Semantic proximity Read ↗

Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity.Semantic proximity Read ↗

Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients.Semantic proximity Read ↗

Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes.Semantic proximity Read ↗

Protective role of TGF-β1 (-509C>T, rs1800469) single-nucleotide polymorphism against radiation toxicities in locally advanced head and neck cancer.Semantic proximity Read ↗

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The late radiotherapy normal tissue injury phenotypes of telangiectasia, fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes.Semantic proximity Read ↗

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