Article
Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response.
Hepatology (Baltimore, Md.) - 1 Jan 2012
Asahina Yasuhiro, Tsuchiya Kaoru, Muraoka Masaru, Tanaka Keisuke, Suzuki Yuichiro, Tamaki Nobuharu, Hoshioka Yoshihide, Yasui Yutaka, Katoh Tomoji, Hosokawa Takanori, Ueda Ken, Nakanishi Hiroyuki, Itakura Jun, Takahashi Yuka, Kurosaki Masayuki, Enomoto Nobuyuki, Nitta Sayuri, Sakamoto Naoya, Izumi Namiki
Abstract excerpt
UNLABELLED: Innate immunity plays an important role in host antiviral response to hepatitis C viral (HCV) infection. Recently, single nucleotide polymorphisms (SNPs) of IL28B and host response to peginterferon α (PEG-IFNα) and ribavirin (RBV) were shown to be strongly associated. We aimed to determine the gene expression involving innate immunity in IL28B genotypes and elucidate its relation to response to...
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