Article
Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies.
Vaccine - 7 Jun 2010
Duan Hongying, Struble Evi, Zhong Lilin, Mihalik Kathleen, Major Marian, Zhang Pei, Feinstone Stephen, Feigelstock Dino
Abstract excerpt
Mutations arising in neutralizing epitopes of hepatitis C virus may play a role in the ability of the virus to escape control by neutralizing antibodies and in the establishment of chronic infections. An amino-acid substitution, Q412H, within a major conserved neutralization epitope EP I (aa 412-426) in the E2 glycoprotein is observed in chronic HCV carriers. We found that naturally acquired polyclonal EP...
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