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Article

Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1992

Weiner A J, Geysen H M, Christopherson C, Hall J E, Mason T J, Saracco G, Bonino F, Crawford K, Marion C D, Crawford K A

Abstract excerpt

E2/nonstructural protein 1, the putative envelope glycoprotein (gp72) of HCV, possesses an N-terminal hypervariable (E2 HV) domain from amino acids 384 to 414 of unknown significance. The high degree of amino acid sequence variation in the E2 HV domain appears to be comparable to that observed in...

Topics

Amino Acid Sequence
Cloning, Molecular
DNA, Viral
Enzyme-Linked Immunosorbent Assay
Genetic Variation
Hepacivirus
Hepatitis C
Humans
Molecular Sequence Data
Peptides
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Probability

Protein Conformation

RNA, Viral

Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1314389
DOI: 10.1073/pnas.89.8.3468
PMCID: PMC48889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1314389-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections.PMID 1314389Read ↗

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