Article
Determination of the human antibody response to the neutralization epitopes encompassing amino acids 313-327 and 432-443 of hepatitis C virus E1E2 glycoproteins.
PloS one - 1 Jan 2013
Liu Ruyu, Rao Huiying, Wang Jianghua, Xie Xingwang, Jiang Dong, Pan Xiaoben, Zhao Ping, Zhang Henghui, Wei Lai
Abstract excerpt
It has been reported that monoclonal antibodies (MAbs) to the E1E2 glycoproteins may have the potential to prevent hepatitis C virus (HCV) infection. The protective epitopes targeted by these MAbs have been mapped to the regions encompassing amino acids 313-327 and 432-443. In this study, we synthesized these two peptides and tested the reactivity of serum samples from 336 patients, 210 of which were from Chronic...
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