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Article

Repeated exposure to heterologous hepatitis C viruses associates with enhanced neutralizing antibody breadth and potency

19 May 2022

Abstract excerpt

A prophylactic hepatitis C virus (HCV) vaccine that elicits neutralizing antibodies could be key to HCV eradication. However, the genetic and antigenic properties of HCV envelope (E1E2) proteins capable of inducing anti-HCV broadly neutralizing antibodies (bNAbs) in humans have not been defined. Here, we investigated the development of bNAbs in longitudinal plasma of HCV-infected persons with persistent infection...

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PMID: 35588376
DOI: 10.1172/jci160058

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