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Article

Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2009

Zhang Pei, Zhong Lilin, Struble Evi Budo, Watanabe Hisayoshi, Kachko Alla, Mihalik Kathleen, Virata Maria Luisa, Alter Harvey J, Feinstone Stephen, Major Marian

Abstract excerpt

Using human immune globulins made from antihepatitis C virus (HCV)-positive plasma, we recently identified two antibody epitopes in the E2 protein at residues 412-426 (epitope I) and 434-446 (epitope II). Whereas epitope I is highly conserved among genotypes, epitope II varies. We discovered that epitope I was implicated in HCV neutralization whereas the binding of non-neutralizing antibody to epitope II...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19380744
DOI: 10.1073/pnas.0902749106
PMCID: PMC2670884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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