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Article

Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans.

Cytoskeleton (Hoboken, N.J.) - 1 Oct 2012

Pittman Kelly J, Skop Ahna R

Abstract excerpt

PAR proteins are key regulators of cellular polarity and have links to the endocytic machinery and the actin cytoskeleton. Our data suggest a unique role for PAR proteins in cytokinesis. We have found that at the onset of cytokinesis, anterior PAR-6 and posterior PAR-2 proteins are redistributed to the furrow membrane in a temporal and spatial manner. PAR-6 and PAR-2 localize to the furrow membrane during...

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Identifiers

PMID: 22887994
DOI: 10.1002/cm.21053
PMCID: PMC3650724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans.PMID 22887994Read ↗

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.Semantic proximity Read ↗

The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo.Semantic proximity Read ↗

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.Semantic proximity Read ↗

Mutations in the par genes of Caenorhabditis elegans affect cytoplasmic reorganization during the first cell cycle.Semantic proximity Read ↗

Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases.Semantic proximity Read ↗

RAB-5 controls the cortical organization and dynamics of PAR proteins to maintain C. elegans early embryonic polarity.Semantic proximity Read ↗

PAR-3 mediates the initial clustering and apical localization of junction and polarity proteins during C. elegans intestinal epithelial cell polarization.Semantic proximity Read ↗

Apical PAR complex proteins protect against programmed epithelial assaults to create a continuous and functional intestinal lumenSemantic proximity Read ↗

The PAR proteins: fundamental players in animal cell polarization.Semantic proximity Read ↗

PAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in Caenorhabditis elegans embryos.Semantic proximity Read ↗

PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.Semantic proximity Read ↗

The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Semantic proximity Read ↗

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