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Article

Association of polymorphisms in RGS4 and expression of RGS transcripts in the brains of human alcoholics.

Brain research - 22 Jun 2010

Ho Ada M-C, MacKay Rachel K, Dodd Peter R, Lewohl Joanne M

Abstract excerpt

Chronic alcoholism leads to neurotoxic effects in the central nervous system. Neuroadaptive changes in the brain may lead to tolerance to, and dependence on, alcohol as a result of alterations in synaptic complexity. G-proteins are negatively regulated by RGS proteins, which are integral to many neural pathways that include neurotransmission, hormonal responses, and chemotactic signals. These considerations,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20430014
DOI: 10.1016/j.brainres.2010.04.049
PMCID: PMC2902459

Genes

RGS4
RGS7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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