Article
Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4).
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2006
Rizig Mie A, McQuillin Andrew, Puri Vinay, Choudhury Khalid, Datta Susmita, Thirumalai Srinivasa, Lawrence Jacob, Quested Digby, Pimm Jonathan, Bass Nicholas, Lamb Graham, Moorey Helen, Badacsonyi Allison, Kelly Katie, Morgan Jenny, Punukollu Bhaskar, Kandasami Gomathinayagam, Curtis David, Gurling Hugh
Abstract excerpt
The chromosome 1q23.3 region, which includes the RGS4 gene has been implicated in genetic susceptibility to schizophrenia by two linkage studies with lod scores of 6.35 and 3.20 and with positive lod between 2.00 and 3.00 scores in several other studies. Reduced post mortem RGS4 gene expression in the brain of schizophrenics was reported as well as positive allelic association between markers at the RGS4 gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.