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Article

Linkage disequilibrium patterns and functional analysis of RGS4 polymorphisms in relation to schizophrenia.

Schizophrenia bulletin - 1 Jan 2008

Chowdari Kodavali V, Bamne Mikhil, Wood Joel, Talkowski Michael E, Mirnics Karoly, Levitt Pat, Lewis David A, Nimgaonkar Vishwajit L

Abstract excerpt

The regulator of G-protein signaling 4 (RGS4, chromosome 1q23.3) plays a critical role in G-protein function. Four common single-nucleotide polymorphisms (SNPs) localized between the 5' upstream sequence and the first intron, as well as 2 haplotypes derived from these SNPs may confer liability to schizophrenia (SZ). However, the pattern of associations varies among samples. To help clarify the putative...

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Identifiers

PMID: 17515439
DOI: 10.1093/schbul/sbm042
PMCID: PMC2632380

Genes

RGS4
MAF

Provenance

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