Article
RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity.
Human molecular genetics - 15 Sept 2006
Lipska Barbara K, Mitkus Shruti, Caruso Mark, Hyde Thomas M, Chen Jingshan, Vakkalanka Radhakrishna, Straub Richard E, Weinberger Daniel R, Kleinman Joel E
Abstract excerpt
Linkage, association and postmortem studies have implicated regulator of G-protein signaling 4 (RGS4), which negatively modulates signal transduction at G-protein-coupled receptors, as a candidate schizophrenia susceptibility gene. We compared RGS4 mRNA expression in the dorsolateral prefrontal cortex (DLPFC), between normal controls and patients with schizophrenia in two independent cohorts (>100 subjects each)...
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