Article
Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses.
Behavioral and brain functions : BBF - 16 May 2012
Zhang Huiping, Wang Fan, Kranzler Henry R, Anton Raymond F, Gelernter Joel
Abstract excerpt
BACKGROUND: RGS17 and RGS20 encode two members of the regulator of G-protein signaling RGS-Rz subfamily. Variation in these genes may alter their transcription and thereby influence the function of G protein-coupled receptors, including opioid receptors, and modify risk for substance dependence. METHODS: The association of 13 RGS17 and eight RGS20 tag single nucleotide polymorphisms (SNPs) was examined with four...
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