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Article

The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels.

Proceedings of the National Academy of Sciences of the United States of America - 11 Mar 2008

Hou Shangwei, Xu Rong, Heinemann Stefan H, Hoshi Toshinori

Abstract excerpt

Carbon monoxide (CO) is a lethal gas, but it is also increasingly recognized as a physiological signaling molecule capable of regulating a variety of proteins. Among them, large-conductance Ca(2+)- and voltage-gated K(+) (Slo1 BK) channels, important in vasodilation and neuronal firing, have been suggested to be directly stimulated by CO. However, the molecular mechanism of the stimulatory action of CO on the...

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Identifiers

PMID: 18316727
DOI: 10.1073/pnas.0800304105
PMCID: PMC2268785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels.PMID 18316727Read ↗

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