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Article

Structural characteristics of the redox-sensing coiled coil in the voltage-gated H+ channel.

The Journal of biological chemistry - 21 Jun 2013

Fujiwara Yuichiro, Takeshita Kohei, Nakagawa Atsushi, Okamura Yasushi

Abstract excerpt

Oxidation is an important biochemical defense mechanism, but it also elicits toxicity; therefore, oxidation must be under strict control. In phagocytotic events in neutrophils, the voltage-gated H(+) (Hv) channel is a key regulator of the production of reactive oxygen species against invading bacteria. The cytoplasmic domain of the Hv channel forms a dimeric coiled coil underpinning a dimerized functional unit....

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Identifiers

PMID: 23667254
DOI: 10.1074/jbc.M113.459024
PMCID: PMC3689942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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