Article
Extending genetic linkage analysis to diffusion tensor images to map single gene effects on brain fiber architecture.
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention - 1 Jan 2009
Chiang Ming-Chang, Avedissian Christina, Barysheva Marina, Toga Arthur W, McMahon Katie L, de Zubicaray Greig I, Wright Margaret J, Thompson Paul M
Abstract excerpt
We extended genetic linkage analysis--an analysis widely used in quantitative genetics--to 3D images to analyze single gene effects on brain fiber architecture. We collected 4 Tesla diffusion tensor images (DTI) and genotype data from 258 healthy adult twins and their non-twin siblings. After high-dimensional fluid registration, at each voxel we estimated the genetic linkage between the single nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.