Article
Gene network effects on brain microstructure and intellectual performance identified in 472 twins.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jun 2012
Chiang Ming-Chang, Barysheva Marina, McMahon Katie L, de Zubicaray Greig I, Johnson Kori, Montgomery Grant W, Martin Nicholas G, Toga Arthur W, Wright Margaret J, Shapshak Paul, Thompson Paul M
Abstract excerpt
A major challenge in neuroscience is finding which genes affect brain integrity, connectivity, and intellectual function. Discovering influential genes holds vast promise for neuroscience, but typical genome-wide searches assess approximately one million genetic variants one-by-one, leading to intractable false positive rates, even with vast samples of subjects. Even more intractable is the question of which...
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