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Article

Genetic Analysis of Cortical Thickness and Fractional Anisotropy of Water Diffusion in the Brain

1 Jan 2011

Abstract excerpt

OBJECTIVES: The thickness of the brain's cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated by common biological mechanisms. We employed four types of genetic analyses to localize individual genes acting pleiotropically upon these phenotypes. METHODS:...

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PMID: 22028680
DOI: 10.3389/fnins.2011.00120

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