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Article

Molecular effects of familial hypertrophic cardiomyopathy-related mutations in the TNT1 domain of cTnT.

Journal of molecular biology - 3 Aug 2012

Manning Edward P, Tardiff Jil C, Schwartz Steven D

Abstract excerpt

Familial hypertrophic cardiomyopathy (FHC) is one of the most common genetic causes of heart disease. Approximately 15% of FHC-related mutations are found in cTnT [cardiac troponin (cTn) T]. Most of the cTnT FHC-related mutations are in or flanking the N-tail TNT1 domain that directly interacts with overlapping tropomyosin (Tm). We investigate two sets of cTnT mutations at opposite ends of TNT1, mutations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

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Source

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Identifiers

PMID: 22579624
DOI: 10.1016/j.jmb.2012.05.008
PMCID: PMC3545441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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