Evolutionary and physics-guided modulation of Ca 2 + sensitivity in Cardiac troponin C.

Abstract excerpt

CONTEXT: Precise tuning of Ca 2 + sensitivity is essential for cardiac contractility, requiring modulation of force generation without disrupting native regulatory control. Cardiac troponin C acts as the primary Ca 2 + sensor, where subtle perturbations at the regulatory EF-hand site II can influence thin-filament activation. Here, we present an integrated evolutionary and physics-guided modeling framework to...

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• Allosteric Regulation
• Calcium
• EF Hand Motifs
• Evolution, Molecular
• Molecular Dynamics Simulation