Article
The loss of functional caspase-12 in Europe is a pre-neolithic event.
PloS one - 1 Jan 2012
Hervella Montserrat, Plantinga Theo S, Alonso Santos, Ferwerda Bart, Izagirre Neskuts, Fontecha Lara, Fregel Rosa, van der Meer Jos W M, de-la-Rúa Concepcion, Netea Mihai G
Abstract excerpt
BACKGROUND: Caspase-12 (CASP12) modulates the susceptibility to sepsis. In humans, the "C" allele at CASP12 rs497116 has been associated with an increased risk of sepsis. Instead, the derived "T" allele encodes for an inactive caspase-12. Interestingly, Eurasians are practically fixed for the inactive variant, whereas in Sub-Saharan Africa the active variant is still common (~24%). This marked structure has been...
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