Article
Nuclear receptor Nurr1 is expressed in and is associated with human restenosis and inhibits vascular lesion formation in mice involving inhibition of smooth muscle cell proliferation and inflammation.
Circulation - 11 May 2010
Bonta Peter I, Pols Thijs W H, van Tiel Claudia M, Vos Mariska, Arkenbout E Karin, Rohlena Jakub, Koch Karel T, de Maat Moniek P M, Tanck Michael W T, de Winter Robbert J, Pannekoek Hans, Biessen Erik A L, Bot Ilze, de Vries Carlie J M
Abstract excerpt
BACKGROUND: Restenosis is the major drawback of percutaneous coronary interventions involving excessive activation and proliferation of vascular smooth muscle cells (SMCs). The nuclear receptor Nurr1 is an early response gene known mainly for its critical role in the development of dopamine neurons. In the present study, we investigated Nurr1 in human and experimental vascular restenosis. METHODS AND RESULTS: In...
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