Article
A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention.
Human molecular genetics - 1 Dec 2011
Sampietro M Lourdes, Trompet Stella, Verschuren Jeffrey J W, Talens Rudolf P, Deelen Joris, Heijmans Bastiaan T, de Winter Robbert J, Tio Rene A, Doevendans Pieter A F M, Ganesh Santhi K, Nabel Elizabeth G, Westra Harm-Jan, Franke Lude, van den Akker Erik B, Westendorp Rudi G J, Zwinderman Aeilko H, Kastrati Adnan, Koch Werner, Slagboom P Eline, de Knijff Peter, Jukema J Wouter
Abstract excerpt
Percutaneous coronary intervention (PCI) has become an effective therapy to treat obstructive coronary artery diseases (CAD). However, one of the major drawbacks of PCI is the occurrence of restenosis in 5-25% of all initially treated patients. Restenosis is defined as the re-narrowing of the lumen of the blood vessel, resulting in renewed symptoms and the need for repeated intervention. To identify genetic...
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