Article
Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic mice.
Circulation - 17 Sept 2002
Arkenbout E Karin, de Waard Vivian, van Bragt Maaike, van Achterberg Tanja A E, Grimbergen Jos M, Pichon Bruno, Pannekoek Hans, de Vries Carlie J M
Abstract excerpt
BACKGROUND: Smooth muscle cells (SMCs) play a key role in intimal thickening in atherosclerosis and restenosis. The precise signaling pathways by which the proliferation of SMCs is regulated are largely unknown. The TR3 orphan receptor, the mitogen-induced nuclear orphan receptor (MINOR), and the nuclear receptor of T cells (NOT) are a subfamily of transcription factors belonging to the nuclear receptor...
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