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Article

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

Molecular and cellular biology - 1 Jul 2010

Stempfle Denise, Kanwar Ritu, Loewer Alexander, Fortini Mark E, Merdes Gunter

Abstract excerpt

The intramembrane aspartyl protease gamma-secretase plays a fundamental role in several signaling pathways involved in cellular differentiation and has been linked with a variety of human diseases, including Alzheimer's disease. Here, we describe a transgenic Drosophila model for in vivo-reconstituted gamma-secretase, based on expression of epitope-tagged versions of the four core gamma-secretase components,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20421416
DOI: 10.1128/MCB.00030-10
PMCID: PMC2897587

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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