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Article

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase.

Journal of visualized experiments : JoVE - 24 Jun 2025

Futai Eugene, Shiina Mio, Dai Ying, Daoudi Khadija, Hidaka Masafumi, Ogawa Tomohisa

Abstract excerpt

γ-Secretase is a protease complex embedded in the cell membrane, consisting of the catalytic presenilin subunits (PS1 or PS2) and three additional co-factors: nicastrin, Aph-1, and Pen2. It cleaves the transmembrane domains of type-I transmembrane proteins, such as the amyloid precursor protein (APP) and Notch. The cleavage of APP generates the amyloid β peptides (Aβ), which accumulate in patients with...

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Identifiers

PMID: 40658746
DOI: 10.3791/67733

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APP

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