A reporter for amyloid precursor protein gamma-secretase activity in Drosophila.

Abstract excerpt

A key event in the pathogenesis of Alzheimer's disease (AD) is the deposition of senile plaques consisting largely of a peptide known as beta-amyloid (Abeta) that is derived from the amyloid precursor protein (APP). A proteolytic activity called gamma-secretase cleaves APP in the transmembrane domain and is required for Abeta generation. Aberrant gamma-secretase cleavage of APP underlies the majority of early...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloid beta-Protein Precursor
• Share to Amyloid Precursor Protein Secretases