Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.

doi:10.1073/pnas.0500940102

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Article

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 2005

Mastrangelo Peter, Mathews Paul M, Chishti M Azhar, Schmidt Stephen D, Gu Yongjun, Yang Jing, Mazzella Matthew J, Coomaraswamy Janaky, Horne Patrick, Strome Bob, Pelly Heather, Levesque Georges, Ebeling Chris, Jiang Ying, Nixon Ralph A, Rozmahel Richard, Fraser Paul E, St George-Hyslop Peter, Carlson George A, Westaway David

Abstract excerpt

Gamma-secretase depends on presence of presenilins (PS), Nct, Aph-1, and PEN-2 within a core complex. This endoproteolytic activity cleaves within transmembrane domains of amyloid-beta precursor protein (APP) and Notch, and familial Alzheimer's disease (FAD) mutations in PS1 or PS2 genes shift APP cleavage from production of amyloid-beta (Abeta) 40 peptide to greater production of Abeta42. Although studies in...

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PMID: 15951428
DOI: 10.1073/pnas.0500940102
PMCID: PMC1149500

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