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Article

The nucleotide composition of microsatellites impacts both replication fidelity and mismatch repair in human colorectal cells.

Human molecular genetics - 1 Jul 2010

Campregher Christoph, Scharl Theresa, Nemeth Manuela, Honeder Clemens, Jascur Thomas, Boland C Richard, Gasche Christoph

Abstract excerpt

Microsatellite instability is a key mechanism of colon carcinogenesis. We have previously studied mutations within a (CA)13 microsatellite using an enhanced green fluorescent protein (EGFP)-based reporter assay that allows the distinction of replication errors and mismatch repair (MMR) activity. Here we utilize this assay to compare mutations of mono- and dinucleotide repeats in human colorectal cells. HCT116 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20421367
DOI: 10.1093/hmg/ddq175
PMCID: PMC2883347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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