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Article

Apoptosis of beta cells in diabetes mellitus.

DNA and cell biology - 1 Nov 2014

Anuradha Rachakatla, Saraswati Mudigonda, Kumar Kishore G, Rani Surekha H

Abstract excerpt

Diabetes mellitus is a multifactorial metabolic disorder characterized by hyperglycemia. Apoptosis in beta cells has been observed in response to diverse stimuli, such as glucose, cytokines, free fatty acids, leptin, and sulfonylureas, leading to the activation of polyol, hexosamine, and diacylglycerol/protein kinase-C (DAG/PKC) pathways that mediate oxidative and nitrosative stress causing the release of...

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Identifiers

PMID: 25093391
DOI: 10.1089/dna.2014.2352

Genes

FOXO1
GLIS3
NOS2
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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