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Article

The miRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells

5 Jul 2019

Abstract excerpt

miRNAs are a class of small non-coding RNAs that regulate gene expression. Type 1 diabetes is an autoimmune disease characterized by insulitis (islets inflammation) and pancreatic beta cell destruction. The pro-inflammatory cytokines interleukin 1 beta (IL1B) and interferon gamma (IFNG) are released during insulitis and trigger endoplasmic reticulum (ER) stress and expression of pro-apoptotic members of the BCL2...

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PMID: 31277072
DOI: 10.1530/jme-19-0066

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